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                        <li><a href="SNP_PGC2.html"> PGC2 GWAS</a></li>
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                        <li><a href="geneList.html">Gene Browser System</a>
                            
                        <li><a href="Gene_PGC3_SMR.html">Genes identified by SMR</a></li>
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            <h3 align="center">Genes Identified by GWAS</h3>
            <hr>

            <form action="/dbBIP/Genes_Identified_by_GWAS_resule" method="post" class="form-inline" role="form">
                <div class="col-md-8">
                    <!-- input Genes -->
                    <div class="panel panel-primary">
                        <div class="panel-heading">
                            <h3 class="panel-title">Step1: select a GWAS</h3>
                        </div>
                        <div class="panel-body">
                            <input type="radio" name="gwas" value="PGC2" id="PGC2" checked="checked"> PGC2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
                            <input type="radio" name="gwas" value="PGC3" id="pgc3"> PGC3
                        </div>
                    </div>

                    <!-- select dataset -->
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                        <div class="panel-heading">
                            <h3 class="panel-title">Step2: input genes</h3>
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                        <div class="panel-body">
                            <!--<input type="text" class="form-control" placeholder="Username" aria-describedby="sizing-addon1" name="snp">-->
                            <textarea class="form-control" id="gene" maxlength="200" name="gene" rows="5" style="width: 100%;">
</textarea>
                        </div>
                    </div>
                    <p><span class="snp-or">or - Input a region</span></p>

                    <!-- input region -->
                    <div class="panel panel-info">
                        <div class="panel-heading">
                            <h3 class="panel-title">Step2: input a region</h3>
                        </div>
                        <div class="panel-body">
                            <div class="snp-region form-group">
									<span style="display: inline-block; padding-bottom: 3px;">
										<label style="font-weight: bold;" for="chromosome" class="form-label">Chromosome&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</label>
										<select id="chromosome" name="chromosome" class="form-control">
											<option value="1">chr1</option>
											<option value="2">chr2</option>
											<option value="3">chr3</option>
											<option value="4">chr4</option>
											<option value="5">chr5</option>
											<option value="6">chr6</option>
											<option value="7">chr7</option>
											<option value="8">chr8</option>
											<option value="9">chr9</option>
											<option value="10">chr10</option>
											<option value="11">chr11</option>
											<option value="12">chr12</option>
											<option value="13">chr13</option>
											<option value="14">chr14</option>
											<option value="15">chr15</option>
											<option value="16">chr16</option>
											<option value="17">chr17</option>
											<option value="18">chr18</option>
											<option value="19">chr19</option>
											<option value="20">chr20</option>
											<option value="21">chr21</option>
											<option value="22">chr22</option>
											<option value="X">chrX</option>
										</select>
									</span>
                            </div>

                            <div class="snp-region form-group">
                                <label style="font-weight: bold;" for="start" class="form-label">Genome Position</label>
                                <div class="input-group">
                                    <input class="form-control" id="start" maxlength="20" name="start" type="text" value="">
                                    <span class="input-group-addon">-</span>
                                    <input class="form-control" id="end" maxlength="20" name="end" type="text" value="">
                                    <span class="input-group-addon">bp</span>
                                </div>
                            </div>
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                    </div>
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                        <div class="panel-heading"><a href="#" style="cursor:hand"><span class="glyphicon glyphicon-hand-right" aria-hidden="true"></span> Example for GWAS</a>
                        </div>
                        <div class="panel-body">
                            PGC3<br>
                        </div>
                    </div>

                    <div class="panel panel-default" style="margin-top:13px;">
                        <div class="panel-heading"><a href="#" style="cursor:hand"><span class="glyphicon glyphicon-hand-right" aria-hidden="true"></span> Example for genes</a>
                        </div>
                        <div class="panel-body">
                            SMIM4<br>
                            ANKRD23<br>
                            KANSL3<br>
                        </div>
                    </div>
                    <p><span class="snp-or">or - Input a region</span></p>

                    <div class="panel panel-default" style="margin-top:12px;">
                        <div class="panel-heading"><a href="#" style="cursor:hand"><span class="glyphicon glyphicon-hand-right" aria-hidden="true"></span> Example for region</a>
                        </div>
                        <div class="panel-body">
                            Chromosome chr16<br>
                            Genome Position 67708897 - 68305708 bp
                        </div>
                    </div>

                </div>

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            <div class="col-md-12 panel-note">
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                    <div class="panel-heading">
                        <h4 class="panel-title"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span> Where does this data come from?</h4>
                    </div>
                    <div class="panel-body">
                        <p class="note-source">
                            &nbsp;&nbsp;&nbsp;&nbsp;In 2019, the Bipolar disorder Working Group of the Psychiatric
                            Genomics Consortium (PGC) reported a multi-stage bipolar disorder genome-wide association
                            study (PGC2 GWAS) of up to 20,352 cases and 31,358 controls of European descent. In this
                            study, 30 loci were genome-wide significant, including 20 newly identified loci (Stahl EA et
                            al. Genome-wide association study identifies 30 loci associated with bipolar disorder.
                            Nature Genetics, 51(5):793-803. [ <a href='javascript:;' target='_blank'>PMID: 31043756</a>]).
                            the Psychiatric Genomics Consortium. 2014. Biological insights from 108
                            schizophrenia-associated genetic loci. Nature, 511(7510):421-427.
                            <br>
                            &nbsp;&nbsp;&nbsp;&nbsp;In 2021, the Bipolar disorder Working Group of the Psychiatric
                            Genomics Consortium (PGC) reported a new performed a genome-wide association study (PGC3
                            GWAS) of 41,917 bipolar disorder cases and 371,549 controls of European descent, which
                            identified 64 associated genomic loci. In this study, of the 64 genome-wide significant
                            loci, 33 are novel discoveries (ie. loci not overlapping with any locus previously reported
                            as genome-wide significant for bipolar disorder). (Mullins et al. Genome-wide association
                            study of more than 40,000 bipolar disorder cases provides new insights into the underlying
                            biology. Nature Genetics, 53(6):817-829. [<a href='javascript:;' target='_blank'>PMID: 34002096</a>]).

                            <br>
                            &nbsp;&nbsp;&nbsp;&nbsp;It should be noted that these two GWAS studies were not fully
                            independent. <br>
                            &nbsp;&nbsp;&nbsp;&nbsp;<b>If you used this data, please cite the reletive reference.</b>
                        </p>
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